Aberrant activity of specific transporters—such as MCU complex-induced Ca2+ overload triggering mPTP opening in ischemia–reperfusion injury, VDAC1 oligomerization facilitating ROS leakage in atherosclerosis, and TRPC3/6-mediated Ca2+ influx promoting fibrosis—orchestrates hallmark features of CVDs. This evidence concerns the gene MCU and atherosclerosis.