The relevance of this axis to thyroid cancer is unequivocal: studies demonstrate that CD73 is significantly overexpressed in papillary carcinomas (PTC), especially at the invasive tumor fronts, and its presence is linked to a poorer clinical prognosis, validating it as a high-priority therapeutic target [22,24,25,26]. The gene discussed is NT5E; the disease is thyroid gland papillary carcinoma.