To date, single-nucleotide polymorphisms (SNPs) in 15 genes have been linked to progressive AIS: ER, IGF1, MATN1, CALM1, TPH-1, NFT3, IL-17RC, LBX1, LAPTM4B, BNC2, FBN1/, TIMP 2, SOX9, CDH7, and MIR4300 [6,7,8]. The gene discussed is FBN1; the disease is androgen insensitivity syndrome.