Compared to non-AIS tissues of the same type, AIS tissues typically showed lower gene expression levels: PCDH10 and FBN2 in AIS bone (p = 0.0176 and p = 0.0128, respectively); CRTC1, FRZB, LRP6, and MSTN in AIS muscle (p = 0.0410, p = 0.0324, p = 0.0069, and p = 0.0276, respectively); PCDH10 in AIS ligament (p = 0.0259); and APC, CTNBB1, FRZB, FBN2, and ESR2 in peripheral blood (p = 0.0034, p = 0.0009, p = 0.0343, p = 0.0224, p = 0.0034, and p = 0.0019, respectively). The gene discussed is ESR2; the disease is androgen insensitivity syndrome.