Several recent studies have implicated a range of genes, including Sv2b, Park2, Sept5, and Atxn2, in the development of neurological disorders, cognitive impairment, and neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) [52,53,102]. This evidence concerns the gene PRKN and early-onset autosomal dominant Alzheimer disease.