In colorectal carcinoma (CRC), pathognomonic amplification of tumour-promoting immunocytokine networks—exemplified by the overabundance of tumour necrosis factor superfamily ligands, IL-1 family members, pleiotropic IL-6–type glycoproteins, and Th17-associated effector cytokines—propels disease evolution. The gene discussed is IL1B; the disease is neoplasm.