In an independent clinical evaluation encompassing middle-aged and elderly cohorts with established Type 2 diabetes mellitus and coexistent periodontitis, therapeutic administration of atorvastatin precipitated a marked attenuation in pro-inflammatory cytokine burden, evidenced by substantially diminished IL-6 and TNF-α titers within both gingival crevicular exudates and salivary secretions—findings congruent with a localized downmodulation of inflammatory activity. Here, TNF is linked to type 2 diabetes mellitus.