CGA has been shown to modulate the production of inflammatory mediators such as TNF-α, IL-1β, IL-6, IL-8, NO, and PGE2, and regulate key signaling pathways such as NF-κB, MAPK, and Nrf2, providing protective effects against cardiovascular disease and diabetes mellitus [63]. The gene discussed is CXCL8; the disease is cardiovascular disorder.