A recent study in NSCLC further revealed that CIP2A binds to pyruvate kinase M2 (PKM2), inducing tetramer formation, redirecting PKM2 to mitochondria, and enhancing oxidative phosphorylation and B-cell lymphoma 2 (Bcl-2) phosphorylation—thereby boosting tumor cell energy metabolism and survival [22]. Here, BCL2 is linked to neoplasm.