Among these pathways, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling is frequently dysregulated in HCC and plays a central role in tumor development, angiogenesis, metastasis, and chemoresistance [11]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.