Anti-Mi-2 (anti-nuclear helicase), anti-MDA-5 (anti-melanoma differentiation-associated gene 5), anti-NXP-2 (anti-nuclear matrix protein 2), anti-TIF-1γ (anti-transcriptional intermediary factor 1), and anti-SAE-1/2 (anti-small ubiquitin-like modifier-1 activating enzyme) are MSA most commonly associated with DM. The gene discussed is IFIH1; the disease is diabetes mellitus.