IGFBP-2 and IGFBP-5 emerged as significant independent predictors of LGA birth in adjusted models (OR = 2.515 and 2.402, respectively; p < 0.001), consistent with prior studies linking first-trimester IGF-1 and IGF-1/IGFBP-1 ratios to macrosomia [23]. Here, IGF1 is linked to Large for gestational age.