CD4 and neoplasm: PAK4KO tumours exhibited more pronounced regression, and not only mirrored the activation of the markers mentioned above but also showed a significant increase in CD11c+ and MHC-II+ dendritic cell subsets, highlighting a distinct role for PAK4 in suppressing dendritic cell-mediated immune responses, e.g., the requirement for CD4+ T-cell maturation and function [44,45].