However, the increased ratios of NG2+/CD31+ and αSMA+/CD31+ in PAK1KO and PAK4KO tumours indicated that, despite the overall reduction in vessel density, the remaining vessels exhibited increased pericyte coverage, suggestive of vascular normalisation [22,29] (Figure 1H,I,Q,R). This evidence concerns the gene ACTA1 and neoplasm.