PAK1KO did not affect the expression of ICAM-1 by pancreatic cancer cells but increased the expression of VCAM-1 by pancreatic cancer cells about two times (Figure 4C), suggesting that PAK1KO stimulated the expression of ICAM-1 of non-tumour stromal cells rather than the tumour cells, and that PAK1KO increased the expression of VCAM-1 of non-tumour stromal cells more than that of tumour cells. Here, ICAM1 is linked to familial pancreatic carcinoma.