IL5 and helminthiasis: Considering high FeNO levels and the fact that IL-5 is detectable at much high concentration in the induced sputum of asthmatics, one might hypothesize that divergent control mechanisms of the type 2 responses in health and disease exists, with very strong type 2 responses in the lung of allergic asthmatics, and only a subtle fine-tuning of this local, pulmonary production of type 2 mediators by helminth infections otherwise associated with systemically enhanced type 2 responses.