CCND1 and inflammatory skin disease: MIRI, EPL, and RELA had no significant effect on proliferation-related genes (Aqp3, Krt5, Ccnd1), whereas MR/GR double knockout (DKO) mice exhibit increased keratinocyte proliferation, although it is possible that this effect could be related to inflammation, which often leads to hyperplasia in inflammatory skin disorders [7,29].