MAPK3 and neoplasm: The upregulation of DUSP1 by tumour-supporting genes has also been described in a study performed in TNBC MDA-MB-231 and MDA-MB-468 cells, showing that β2-adrenergic receptor, which may act as a protumoural gene [27], determines an increase in DUSP1 and a reduction of ERK1/2 phosphorylation.