Finally, Cheng and colleagues found that the administration of baculovirus-derived recombinant DUSP1 reduced the level of ERK1/2 phosphorylation in cell lines from different types of cancer (GC-7901, MCF-7, HeLa, A49, PC-2, and HepG2) and decreased the proliferation of HeLa cells [85]. This evidence concerns the gene MAPK3 and cancer.