Interestingly, a later IHC study performed using human specimens from 66 human lung adenocarcinoma (LUAD) showed that DUSP6 expression positively correlates with a lower expression of the proliferation marker KI67, and lower histological grade, likely acting as a negative feedback regulator of ERK1/2 in LUAD progression [128]. This evidence concerns the gene MAPK3 and lung adenocarcinoma.