Furthermore, a recent study reported that the transcription factor ZNF251 inhibits the expression of DUSP6 by directly binding to its promoter region and activates ERK1/2 signalling in NSCLC cell lines (A549, H520, H23, H460, and SPC-A-1) and in a mouse model with a KRAS mutation (G12D) [135]. The gene discussed is MAPK3; the disease is non-small cell lung carcinoma.