In line with the above observed tumour suppressor roles of DUSP6, in A549 and H1975 NSCLC cells, inhibition of GPx3, a ROS scavenger, determined ROS-induced inactivation of DUSP6 as well as an increase in ERK1/2 phosphorylation and cell proliferation [134]. The gene discussed is MAPK3; the disease is neoplasm.