MAPK3 and non-small cell lung carcinoma: Mechanistically, DUSP6 KD in NSCLC cells expressing high levels of DUSP6 (H441 cells) significantly increased ERK1/2 phosphorylation and cell proliferation, whereas overexpression of DUSP6 in low DUSP6-expressing cells (H1975) significantly reduced ERK1/2 phosphorylation and cellular proliferation and promoted apoptosis.