MAPK3 and neoplasm: More recently, in line with a possible antitumoural activity of DUSP1, Doronzo and colleagues found that in D4M BRAFV600E murine melanoma cells, TFEB silencing prevents DUSP-1 inactivation and reduces ERK1/2 activity and tumour growth, highlighting its critical role in melanoma cell proliferation and metabolic adaptation [84].