In NSCLC, it has been reported that DUSP3 expression is epigenetically repressed by the histone H3 lysine 36 demethylase KDM2A (also called FBXL11 and JHDM1A), which is frequently overexpressed in NSCLC tumours and cell lines, and the high level of expression of which correlates with poor prognosis. This evidence concerns the gene KDM2A and neoplasm.