KD of the stress-induced tumour suppressor gene TP53INP1, which is downregulated in HCC, led to an increase in the invasion of immortalized normal liver (MIHA) and HCC (MHCC97L) cell lines and metastasis in nude mice injected with MHCC97L-siTP53INP1 cells compared with control MHCC97L cells. Here, TP53INP1 is linked to hepatocellular carcinoma.