The same group further reported that simvastatin inhibited IL-1beta, IL-23, TGF-beta, IL-21 and IL-12p70, and induced IL-27 secretion from DCs in RRMS patients, thus providing an inhibitory cytokine milieu for Th17 and Th1-cell differentiation [224]. This evidence concerns the gene IL21 and relapsing-remitting multiple sclerosis.