To further elucidate AML-induced transcriptional alterations in vitro, WT-MSCs isolated from wild-type mice (Supplementary Figure S1B) were characterized by positive expression of MSC-specific markers (Sca-1, CD51, CD44, and CD29) and absence of hematopoietic markers (CD45 and CD31), as previously described [2]. This evidence concerns the gene ITGAV and acute myeloid leukemia.