At the center of this inflammatory process is the NLRP3 inflammasome, an intracellular sensor activated by a wide range of metabolic danger signals that accumulate in obesity, including saturated fatty acids (e.g., palmitate), ceramides, uric acid, high glucose, and islet amyloid polypeptide (IAPP) [45,64,72,93]. This evidence concerns the gene IAPP and obesity due to melanocortin 4 receptor deficiency.