CHEK1 and cancer: Prediction of MR-miRNAs and MR-circRNAs involved in the regulation of 34HR-MNG identified CHEK1 and PIM1 as the unique transcripts entering into a feed-forward loop ceRNA network: CHEK1 and PIM1 are the validated targets of four miRNAs (miR-16-5p, miR-124-3p, miR-193b-3p, and miR-195-5p), described as tumor suppressors in MNG or other cancers in the literature, which, in turn, may be sponged by MR-circRNAs biogenerated by the same CHEK1 and PIM1 host genes (Table 1).