Considering the results of previous studies and the present experiments, it is possible that an increase in plasma FBLN5 may have a protective effect against hydrocephalus; however, due to the progressive natural course of the disease, it is likely that the naturally increased amount of FBLN5 is not enough to prevent the subsequent onset of hydrocephalus or to fully reverse hydrocephalus at that point. The gene discussed is FBLN5; the disease is Hydrocephalus.