This phenomenon of reduced cells’ response to insulin/insulin resistance that leads to hyperinsulinemia can occur due to genetic polymorphisms of tyrosine phosphorylation of the insulin receptor, insulin receptor proteins, and PIP-3 kinase, or abnormalities of the GLUT 4 function, and/or environmental factors [157,158,159,160]. The gene discussed is SLC2A4; the disease is Hyperinsulinemia.