Decreased hsa-miR-185-5p in AD improves the expression of PSEN1 and GSK3β, which further increases Aβ generation.The 3′ UTR of hsa-miR-181c-5p contains a predicted binding site for IL1. In AD patients, IL1 is associated with Aβ generation.hsa-miR-451a correlated with clinical measurements of education (R = 0.477), depression (R = 0.605), and leisure activity (R = 0.411).hsa-miR-664a-3p was upregulated in AD patients, which downregulated CREB1 and BDNF expression levels, thereby leading to a cognitive decline in AD patients. Here, PSEN1 is linked to major depressive disorder.