Accordingly, NKp30-CD28 CAR TCRKO T cells released IFN-γ following co-incubation with several primary AML samples (Figure 4B), although amounts of IFN-γ produced did not always correlate with B7H6 expression levels detected on these AML samples as, e.g., seen for MZ124 (see Figure 2A). This evidence concerns the gene NCR3LG1 and acute myeloid leukemia.