In this study, we firstly uncover that B-cell ST6Gal1/Neu1 ratios inversely forecast the combined remission and low-disease-activity subgroup with DAS28-MCP-12 ≤ 3.6 and SDAI ≤ 11 scores for rheumatoid arthritis (Table 2). This evidence concerns the gene NEU1 and rheumatoid arthritis.