In both animal models and human tissue, increased expression of CD44 in reactive astrocytes has been found in a wide range of neurologic pathologies, including hypoxia/ischemia [60,72], epilepsy [60,73,74,75,76], MS and related experimental models [77,78,79,80], prion disease [81], tuberous sclerosis [82], AD [30,83,84,85], and other neurodegenerative conditions such as Parkinson’s disease (PD) [86] and ALS [52]. This evidence concerns the gene CD44 and prion disease.