Their localization has also been found at the level of the NMJ, where, in the SOD1 model of ALS, the remodeling that follows axonal degeneration and consequent denervation is associated with increased expression of both CD44 and ErbB3 in terminal Schwann cells, supporting a role of CD44 in synaptic plasticity [113]. This evidence concerns the gene CD44 and amyotrophic lateral sclerosis.