On the other hand, BMI1 overexpression (27% of cases, Figure 1C) showed paradoxically significant inverse correlation with FOXP3+ CD3+ TIL (p = 0.008), loss of p27 (p = 0.002), and the combined loss of p21/p27 expression (p = 0.006) (Supplementary Table S2A), tumor size (p = 0.003), and ER negative status (p = 0.049) (Supplementary Table S2B). Here, ESR1 is linked to neoplasm.