For example, siM10 is siRNA that selectively silences the expression of TDP-43 allele with the p.G376D mutation in ALS fibroblasts, reducing cytoplasmic TDP-43 inclusions, and restoring of TDP-43 nuclear localization, oxidative redox, and cell viability [67]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.