TARDBP and amyotrophic lateral sclerosis: Indeed, this class of proteins includes amyloid-β (Aβ), tau, α-synuclein, TDP-43, and huntingtin, and exhibit a high propensity for misfolding and aggregation, which underpins the formation of pathological inclusions such as neurofibrillary tangles, Lewy bodies, and cytoplasmic inclusions characteristic of AD, PD, ALS, and HD, respectively [185,186].