Besides, phthalates, as classic EDCs, can interfere with the negative feedback regulation of the hypothalamic-pituitary-adrenal (HPA) axis by competitively binding to estrogen receptors, thyroid hormone receptors [44], etc. The above research results all indicate the influence of phthalates in depression and the results of molecular docking also confirmed this point. This evidence concerns the gene ESR1 and depressive symptom measurement.