HLA-C and Autoimmunity: In ovarian tissue, integrative methylome–transcriptome profiling revealed coordinated methylation–expression changes in HLA-B and HLA-F, indicating that the enrichment of the T1D pathway is largely driven by signals from the major histocompatibility complex (MHC) region and supporting the involvement of MHC-mediated antigen presentation in crosstalk between PCOS and autoimmunity [52].