POLE and Fanconi anemia: Indeed, it included genes involved in DNA repair mechanisms, such as X-ray Repair Cross Complementing 3 (XRCC3), Fanconi Anemia Complementation Group G (FANCG), Fanconi Anemia Complementation Group A (FANCA), Breast Cancer 1 (BRCA1), Polyhomeotic Homolog 1 (PHC1), BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1), BRCA1-Associated RING Domain 1 (BARD1), Tumor Protein P53 (TP53), Checkpoint Kinase 2 (CHEK2), Vaccinia-Related Kinase 1 (VRK1), and DNA Polymerase Epsilon Catalytic Subunit (POLE).