INS and type 2 diabetes mellitus: Christ-Roberts, C.Y. et al. also reported an improvement of insulin stimulated GDR in patients with T2D after exercising for 8 weeks by gradually increasing intensity (from 60% at the beginning of the study to 70% VO2 max at the end of the intervention), duration (from 20 min at the beginning of the study to 45 min at the end of the intervention), and frequency (three times a week at the beginning of the study to four times a week at the end of the intervention) [27].