Induction of IBD resulted in a non-significant (p > 0.05, n = 6) decrease in mean colonic SOD activity, dropping from 0.14 ± 0.01 to 0.08 ± 0.01 and 013 ± 0.01 u/mg of protein on days 2 and 4, respectively, and recovered to 0.17 ± 0.00 u/mg of protein by day 7. This evidence concerns the gene SOD1 and inflammatory bowel disease.