Suppression of TH signaling with an anti-thyroid drug or targeting the intracellular TH components iodothyronine deiodinases and TH receptors has been shown to protect photoreceptors in LCA RPE65-deficient mice [12,13,14,15,16] and in NaIO3-induced AMD model mice [17,18]. This evidence concerns the gene TH and age-related macular degeneration.