In total, 1578 genes expressed negative regulation after co-infection, including armadillo-like helical domain containing 4 (ARMH4), NME/NM23 nucleoside diphosphate kinase 4 (NME4), FOS-like 2, AP-1 transcription factor subunit (FOSL2), calcium voltage-gated channel subunit alpha1 A (CACNA1A), and unc-45 myosin chaperone B (UNC45B). The gene discussed is NME1; the disease is coinfection.