The interaction between CLDN1 and FGFR2 in IM-resistant GIST was confirmed by immunofluorescence staining and co-immunoprecipitation data (Figure 6A and Figure 6B, respectively), thereby illustrating tight co-localization and interaction between CLDN1 and FGFR2. The gene discussed is FGFR2; the disease is gastrointestinal stromal tumor.