One study has also identified upstream transcription factors related to enzymatic activity in L skin that may contribute to the expression of IL-6, IL-1β, CXCL8, and CXCL10 [13], and another study has found 17 hubs involved in the cell cycle and IFNα-induced genes when comparing L with NL skin in mild and moderate psoriasis [14]. This evidence concerns the gene IL1B and psoriasis.