In GC, overexpression of Wnt ligands (Wnt2, Wnt3, and Wnt5A) and receptors (FZD7 and LRP5/6) is associated with more advanced disease, poorer prognosis, and elevated metastatic potential, while β-catenin and reduced APC expression further underline more aggressive tumor behavior. This evidence concerns the gene LRP5 and neoplasm.