TCF4 and neoplasm: Additionally, it has been demonstrated that fisetin regulates Wnt/β-catenin signaling in colorectal cancer cells by downregulating β-catenin and TCF4, along with their downstream target genes such as cyclin D1 and matrix metalloproteinase 7 (MMP7), thereby attenuating tumor-promoting signaling activity in HT-29 cells [164].