Similarly, findings by Dutra et al. showed that oral squamous cell carcinoma cell lines (SCC-180) treated with cisplatin (CSP) at higher concentrations exhibited significantly reduced HMGB1 expression, whereas cells treated with lower concentrations of CSP, ART, or ART+CSP maintained levels similar to the negative control. The gene discussed is HMGB1; the disease is oral cavity squamous cell carcinoma.