CCR4 and coinfection: The main limitations of our research are as follows, we were not able to determine specific biomarkers (such as IL-2, IFN-γ, CD45RA-, CCR6-, CCR4-, CXCR3+, CCR5+, etc.)to assess the magnitude and ratio between the type 1 and type 2 immune responses, we can not know for certain the onset and duration of the two co-infections, and we performed a limited review of the specialized literature (our search was limited to four databases).