Additionally, Wan et al. achieved specific recognition and binding of the nanocarrier to the asialoglycoprotein receptor (ASGPR) on the surface of hepatocellular carcinoma (HCC) cells by modifying the surface of the metal–organic framework (MOF) with N-acetylgalactosamine (GalNAc), thereby enabling efficient delivery of survivin siRNA. The gene discussed is ASGR1; the disease is hepatocellular carcinoma.