APP and Alzheimer disease: In the murine APP/PS1 AD model, IPA was shown to interact with peroxisome proliferator-activated receptor α (PPARα) and to activate neuroprotective genes, i.e., Bdnf, Pparα, acyl-CoA synthetase, bubblegum family, member 1 (Acsbg1), stearoyl-CoA desaturase 2 (Scd2), and Scd3 [45].