A mixture of indole, indole-3-acetic acid, and IPA upregulated the expression of AhR, decreased the NF-κB and generation of the NLRP3 inflammasome, and lowered the level of proinflammatory cytokines in APP/PS1 mice, a mouse model of Alzheimer’s disease (AD). This evidence concerns the gene NFKB1 and Alzheimer disease.