CNR1 and Cognitive impairment: Moreover, even though BI-5756’s properties as a CETP inhibitor and CB1 agonist may enhance its translational relevance, its potential psychoactive effects, including mood changes, altered memory, and cognitive impairment, as observed with endogenous and exogenous cannabinoids such as THC, along with other side effects, particularly those that are time- and dose-dependent in long-term use, must be carefully monitored and investigated.