GPT and chronic obstructive pulmonary disease: Hao et al. found that 25–100 mg/kg baicalin alleviated pulmonary inflammation, cell apoptosis, and alveolar destruction in COPD models by upregulating HSP72 expression and inhibiting JNK pathway activation without inducing weight loss, liver/kidney dysfunction (as indicated by normal serum concentrations of alanine transaminase [ALT], aspartate transferase [AST], and other markers), or histological damage to lung, liver, and kidney tissues (as evidenced by hematoxylin and eosin staining) [131].