Compound 23 inhibited glycolysis and induced apoptosis in hepatocellular carcinoma (HCC) cells both in vitro and in vivo, through inhibition of HK-2 (which was found to be overexpressed in the majority of HCC tissue) and tumor glycolysis and activation of mitochondria-associated apoptosis [97]. This evidence concerns the gene HK2 and hepatocellular carcinoma.