CDK4 and malignant colon neoplasm: Furthermore, studies showed that astragalin also significantly inhibited the proliferation and diffusion of HCT116 cells by induced apoptosis (by modulation of Bax, Bcl-2, P53, caspase-3, caspase 6, caspase 7, caspase 8, caspase 9 protein express) and cell cycle arrest (by modulation of Cyclin D1, Cyclin E, P21, P27, CDK2, CDK4 protein express) in five human colon cancer cell lines (HCT116, LoVo, SW620, SW480, Caco2); therefore, making it a potential plant-derived antitumor drug for colon cancer [64].