The rice R gene encodes a resistance protein (R-protein) that specifically recognizes the effector encoded by the rice blast avirulence gene (AVR) and induces signal transduction (such as MAPK cascades or Ca+ bursts) to trigger the defense response of ETI, and the effector becomes a ‘non-toxic factor’ (Avr protein), resulting in infection failure [16,17]. The gene discussed is NLRP6; the disease is infection.