Considering the pagetoid spread of melanocytes in Melan A immunostaining, the analyzed melanomas can be divided into three groups: 8 cases showed no pagetoid spread (0; subgroup 1; see Figure 2a–c), 18 cases showed focal suprabasal melanocytes (+1; subgroup 2; see Figure 2d–f), and 10 cases showed extensive pagetoid spread (+2; subgroup 3, re-classified as SSM with prominent nests; see Figure 2g–i). The gene discussed is MLANA; the disease is melanoma.