TPM2 and neoplasm: Additionally, while lower in global rankings, several genes including COL6A3 (extracellular matrix remodeling) [42], FKBP5 (glucocorticoid signaling) [43], IGFBP2 (tumor invasion and angiogenesis) [44], and TPM2 (cytoskeletal stability) [45] appeared prominently in local SHAP plots for specific cancer samples.