Recent cohort studies have reported that low LDL and total cholesterol levels are associated with higher mortality, a phenomenon referred to as the “cholesterol paradox.” A long-term case–control study conducted in Sweden revealed that low LDL-C and total cholesterol levels are associated with increased mortality, while a large acute coronary syndrome cohort in China showed that LDL-C levels <70 mg/dL independently adversely affect long-term survival and are associated with higher CRP levels [34,35]. Here, CRP is linked to acute coronary syndrome.