ESR1 and breast cancer: Receptor genes such as ACVR1B (ALK4), AR, ARFGEF1 (BIG1), CASP8, CASR, CTNNB1, ESR1, FAN1, FGFR2, and PRKN are associated with BC through their roles in cell signaling pathways, which play a role in many cellular processes (including cell growth, differentiation, and apoptosis) and epigenetic regulation [25].