Tumor-suppressor genes, including APC, BARD1, HMMR (RHAMM), KLLN, LZTR1, MCPH1 (BRIT1), MLH1, NF1, RB1CC1 (FIP200), SLC22A18, and SPTBN1, have been found to increase the risk of disease and tumor development [42,43]. This evidence concerns the gene SPTBN1 and neoplasm.