NFKB1 and pancreatitis: Activation of NF-κB during AP leads to the synthesis of numerous cytokines such as TNF-α, IL-1β, IL-2, IL-6-, and IL-18, various chemokines such as IL-8, macrophage inflammatory protein (MIP-1), MCP-1, platelet-activating factor (PAF), and adhesive molecules Activation of NF-kB is an early event in pancreatitis, paralleling trypsinogen activation in acinar cells.